ABSTRACT
Objective To investigate the effects of prostaglandin E1 on proinflammatory and anti-inflammatory cytokines in sepsis patients.Methods One hundred and twenty cases of sepsis in ICU of our hospital were assigned to the groups:A,B,C and D,30 cases in each group.On the basis of conventional therapy,group A was added with prostaglandin El+ Xuebijing injection.The group was treated with prostaglandin E1,while the group C was treated with Xuebijing injection.The changes of APACHE Ⅱ score,Marshall score,anti-inflammatory and pro-inflammatory factors,mechanical ventilation time,ICU treatment time,28 d mortality rate in the 4 grups were observed and compared among 4 groups.Results The APACHE Ⅱ score and Marshall score after treatment in 4 groups were significantly decreased compared with before freatment (P＜0.05),Compared with the group B,C and D,The decrease of APACHE Ⅱ score,Marshace score,IL-1β,IL-6 and TNF-α levels was more significantly(P＜0.05),While the IL-10 level was significantly increastol(P＜0.05);duration of mechanical ventilation,length of stay ICU in were significantly shorter (P＜0.05),28 d mortality was significantly lower (P＜0.05).Conclusion Prostaglandin E1 combined with Xuebijing injection can effectively inhibit the inflammatory response in septic patients and promote the recovery of patients,reduces the mortality rate.
ABSTRACT
Objective To investigate and analyze the value of using real time dynamic blood sugar monitoring during insulin pump treatment process in ICU patients.Methods Sixty-two ICU cases needing insulin intervention due to own blood glucose abnormality in this hospital from February 2015 to February 2016 were selected and divided into the control group and observation group,31 cases in each group.The control group used the fingertip method for measuring blood glucose and simultaneously used the continuous intravenous insulin injection by micropump;the observation group used real time dynamic blood sugar monitoring system to measure blood glucose level.Results The two groups completed the related study without excluded case or fallen out case.The observation group was better than the control group in the aspects of the time reaching target blood sugar level,total treatment time,insulin dosage and hypoglycemia occurrence rate,the difference was statistically significant (P ＜ 0.05).MBG,MAGE,MODD,SDBG and time percent of glucose drift (TBG≥7.8 mmol/L and TBG≤3.9 mmol/L) on 3 d in the observation group were significantly decreased compared with those on 1 d.The two monitoring methods showed significantly positive correlation (r =0.97,P=0.006).Conclusion ICU patients using the real time dynamic blood sugar monitoring system can obviously decrease blood sugar level,and is safe and effective.